中科白癜风医院让天下无白 https://wapjbk.39.net/yiyuanfengcai/yyjs_bjzkbdfyy/TODAY今日发布ESCHeartFailureEarlyRecent,May13,今日发布02篇AMJTRANSPLANTEarlyRecent,May13,今日发布01篇JAMAEarlyRecent,May13,今日发布02篇JAMACardiologyEarlyRecent,May13,今日发布07篇HypertensionJune01,:75(6)今日发布41篇NEJMMay14,:(20)今日发布27篇CirculationEarlyRecent,May14,今日发布01篇ATVBEarlyRecent,May14,今日发布05篇StrokeEarlyRecent,May14,今日发布08篇CirculationResearchEarlyRecent,May14,今日发布01篇ESCHeartFailureEarlyRecent,May14,今日发布01篇RECOMMEND推荐阅读01GLUT1葡萄糖转运蛋白在出生后CNS血管生成和血脑屏障完整性中的作用CirculationResearchresearch-articleKoenVeys,ZhengFan,etc.2小时前等42用户推荐阅读本文Rationale:Endothelialcells(ECs)arehighlyglycolyticandgeneratethemajorityoftheirenergyviathebreakdownofglucosetolactate.Atthesametime,amainroleofECsistoallowthetransportofglucosetothesurroundingtissues.Thefacilitativeglucosetransporterisoform1(GLUT1/Slc2a1)ishighlyexpressedinECsofthecentralnervoussystem(CNS),andisoftenimplicatedinblood-brainbarrier(BBB)dysfunction,butwhetherandhowGLUT1controlsECmetabolismandfunctionispoorlyunderstood.内皮细胞（Endothelialcells，ECs）高度糖酵解，通过葡萄糖分解为乳酸而产生大部分能量。同时，ECs的主要作用是允许葡萄糖向周围组织的转运。易化葡萄糖转运体亚型1（GLUT1/Slc2a1）在中枢神经系统（CNS）的ECs中高表达，常与血脑屏障（BBB）功能障碍有关，但GLUT1是否和如何控制EC代谢和功能尚不清楚。Objective:WeevaluatedtheroleofGLUT1inendothelialmetabolismandfunctionduringpostnatalCNSdevelopmentaswellasattheadultBBB.我们评估了GLUT1在出生后中枢神经系统发育和成人BBB内皮代谢和功能中的作用。MethodsandResults:InhibitionofGLUT1decreasesECglucoseuptakeandglycolysis,leadingtoenergydepletionandtheactivationofthecellularenergysensorAMPK,anddecreasesECproliferationwithoutaffectingmigration.DeletionofGLUT1fromthedevelopingpostnatalretinalendotheliumreducesretinalECproliferationandlowersvascularoutgrowth,withoutaffectingthenumberoftipcells.Incontrast,inthebrain,weobservedalowernumberoftipcellsinadditiontoreducedbrainECproliferation,indicatingthatwithintheCNS,organotypicdifferencesinECmetabolismexist.Interestingly,whenECsbe
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