白癜风的发病原因 http://pf.39.net/bdfyy/bdfjc/181126/6670968.htmlTODAY今日发布CircCardiovascIntervApr01,:13(4)今日发布02篇（共计04篇）CircHeartFailApr01,:13(4)今日发布03篇（共计06篇）CATHETERCARDIOINTEEarlyRecent,Mar26,今日发布01篇CARDIOVASCRESApr01,:(5)今日发布27篇CirculationResearchMar27,:(7)今日发布18篇StrokeEarlyRecent,Mar27,今日发布02篇CirculationResearchEarlyRecent,Mar27,今日发布02篇EuropeanJournalofHeartFailureEarlyRecent,Mar27,今日发布01篇RECOMMEND推荐阅读01肺动脉高压右心室成纤维细胞表观遗传代谢重编程：线粒体代谢中丙酮酸脱氢酶激酶依赖性改变促进右心室纤维化CirculationResearchresearch-articleLianTian,DanchenWu,etc.2小时前等7用户推荐阅读本文Rationale:Rightventricular(RV)fibrosisinpulmonaryarterialhypertension(PAH)contributestoRVfailure(RVF).WhileRVfibrosisreflectschangesinthefunctionofresidentRVfibroblasts(RVfib),thesecellsareunderstudied.肺动脉高压（PAH）右心室（RV）纤维化与RV衰竭（RVF）有关。虽然房室纤维化反映了房室成纤维细胞（RVfib）功能的改变，但这些细胞尚不清楚。Objective:ExaminetheroleofmitochondrialmetabolismofRVfibinRVfibrosisinhumanandexperimentalPAH.探讨RVfib线粒体代谢在人和实验性多环芳烃房室纤维化中的作用。MethodsandResults:MaleSprague-Dawleyratsreceivedmonocrotaline(MCT;60mg/kg)orsaline.Drinkingwatercontainingnosupplementorthepyruvatedehydrogenasekinase(PDK)inhibitordichloroacetatewasstarted7-dayspostMCT.Atweek-4,treadmilltesting,echocardiographyandrightheartcatheterizationwereperformed.TheeffectsofPDKactivationonmitochondrialdynamicsandmetabolism,RVfibproliferation,andcollagenproductionwerestudiedinRVfibincellculture.EpigeneticmechanismsforpersistenceoftheprofibroticRVfibphenotypeinculturewereevaluated.PDKexpressionwasalsostudiedintheRVfibofpatientswithde
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