翻译：和平校对：审核：张莉芸
Abstract
Pulmonaryarterialhypertension(PAH)representsoneofthemainclinicalexpressionsofthevascularchangesinsystemicsclerosis(SSc).LungmicrovascularchangescanplayaroleinthepathogenesisofidiopathicPAH(IPAH)also.TheaimofthisstudyistoinvestigatethepresenceofcapillaroscopicabnormalitiesinpatientswithIPAHandtoevaluatethedifferencesincapillarynailfoldchangesbetweenpatientswithIPAHandpatientswithSScwithandwithoutPAH.
METHODS:
39SScpatients(19withPAH-SSc-PAHand20without-SSc-noPAH),21subjectswithIPAHand20healthysubjectswererecruited.PAHwasdiagnosedbyrightheartcatheterization.Nailfoldvideocapillaroscopywasperformed(NVC)inallrecruitedsubjects;capillaryquantitativeparameters(loopslengthandwidth,capillarydensity,neoangiogenesis)wereevaluatedandasemiquantitativescoringwasused(normal,minorormajorabnormalitiesforhealthycontrolsandIPAHsubjectsandspecificpatterns-early,activeandlate-forSScsubjects)todefinemicrovascularalterations.
RESULTS:
Thepresenceofcapillaroscopicabnormalitieswasdetectedin38,1%subjectswithIPAH;particularly,白癜风早期怎么治疗北京治疗白癜风不复发的医院
